The cloning of GABAB receptors

Gabaa and Gabab Receptors

Since the introduction of the alpha function by Rall in 1967 12], there has been signii-cant progress in our understanding of the molecular events underlying synaptic transmission. Particular receptor types have been identiied and their activation kinetics characterized. It is now possible to develop models of these receptors, using a formalism similar to that introduced by Hodgkin and Huxley 9...

Metabotropic GABAB Receptors

GABAB Receptors Regulate Extrasynaptic GABAA Receptors.

Tonic inhibitory GABA(A) receptor-mediated currents are observed in numerous cell types in the CNS, including thalamocortical neurons of the ventrobasal thalamus, dentate gyrus granule cells, and cerebellar granule cells. Here we show that in rat brain slices, activation of postsynaptic GABA(B) receptors enhances the magnitude of the tonic GABA(A) current recorded in these cell types via a path...

The role of GABAB receptors in imipramine-induced antinociception in experimental model of neuropathic pain

This study was designed to investigate the role of GABAB receptor agents on imipramine-induced antinociception in ligated and non-ligated mice using hot-plate test. The data showed that different doses of morphine (3, 6, and 9 mg/kg) induced a dose-dependent antinociception in ligated and non-ligated mice. However, the opioid response was decreased in ligated animals. Intracerebroventricular (i...

THE ROLE OF GABAb RECEPTORS IN TEMPORAL LOBE EPILEPSY

Temporal lobe epilepsy is the most common partial epilepsy syndrome seen in adult humans. The hippocampus is a key structure in the evolution of temporal lobe seizures. The axons of the dentate granule cells, the mossy fibres, constitute a major hippocampal excitatory input. Inhibitory phenomena at mossy fibre synapses may therefore prevent seizure propagation through the hippocampus. One such ...